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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
20.91
Human Site:
S279
Identified Species:
32.86
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S279
E
G
S
S
D
E
I
S
S
G
V
G
D
S
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
S279
E
G
S
S
D
E
I
S
S
G
V
G
D
S
E
Dog
Lupus familis
XP_531814
1283
145094
Y262
T
K
S
A
L
N
A
Y
S
A
P
Q
N
S
E
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
S279
E
G
S
S
D
D
A
S
S
G
V
G
D
S
D
Rat
Rattus norvegicus
XP_002726765
1361
151628
S282
E
G
S
S
D
E
V
S
S
G
V
G
D
S
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
S383
A
S
S
E
E
A
S
S
G
V
D
E
N
E
A
Frog
Xenopus laevis
NP_001089247
1340
149481
A262
A
S
S
G
V
D
E
A
G
L
S
E
P
D
S
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
N281
K
E
E
E
E
G
V
N
S
G
A
E
E
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
G184
S
T
I
Q
L
A
E
G
A
T
F
Q
E
K
L
Honey Bee
Apis mellifera
XP_392346
1120
127429
S114
D
E
S
E
E
S
D
S
V
S
E
G
V
S
E
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
M180
L
D
K
M
D
K
I
M
D
G
E
G
E
R
K
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
S261
G
L
D
E
D
E
I
S
A
S
E
T
E
S
D
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
R269
D
A
S
T
G
G
V
R
V
S
V
V
E
P
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
E262
L
V
E
E
K
D
E
E
T
S
K
V
N
R
V
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
R236
P
F
T
R
N
I
S
R
D
N
S
K
K
K
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
26.6
N.A.
80
86.6
N.A.
N.A.
13.3
6.6
20
N.A.
0
33.3
26.6
33.3
P-Site Similarity:
100
N.A.
100
40
N.A.
93.3
100
N.A.
N.A.
26.6
20
53.3
N.A.
13.3
46.6
46.6
53.3
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
13.3
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
40
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
7
0
7
0
14
14
7
14
7
7
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
7
7
0
40
20
7
0
14
0
7
0
27
7
20
% D
% Glu:
27
14
14
34
20
27
20
7
0
0
20
20
34
14
34
% E
% Phe:
0
7
0
0
0
0
0
0
0
0
7
0
0
0
0
% F
% Gly:
7
27
0
7
7
14
0
7
14
40
0
40
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
0
0
7
27
0
0
0
0
0
0
0
0
% I
% Lys:
7
7
7
0
7
7
0
0
0
0
7
7
7
14
7
% K
% Leu:
14
7
0
0
14
0
0
0
0
7
0
0
0
0
7
% L
% Met:
0
0
0
7
0
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
7
0
7
0
7
0
0
20
0
0
% N
% Pro:
7
0
0
0
0
0
0
0
0
0
7
0
7
7
0
% P
% Gln:
0
0
0
7
0
0
0
0
0
0
0
14
0
0
0
% Q
% Arg:
0
0
0
7
0
0
0
14
0
0
0
0
0
14
0
% R
% Ser:
7
14
60
27
0
7
14
47
40
27
14
0
0
47
14
% S
% Thr:
7
7
7
7
0
0
0
0
7
7
0
7
0
0
0
% T
% Val:
0
7
0
0
7
0
20
0
14
7
34
14
7
0
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _